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ARA-290 Peptide (Cibinetide)
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EPO-Derived Research Peptide • Research Use Only
ARA-290 Peptide (Cibinetide) — Research Dossier
ARA-290 peptide, also known as cibinetide, is a synthetic peptide derived from a tissue-protective region of erythropoietin (EPO). It has been investigated in preclinical and clinical research involving innate repair receptor signaling, inflammatory pathways, tissue-protective mechanisms, small nerve fibers and neuropathy-related endpoints.
Compound
ARA-290
Research Name
Cibinetide
Peptide Length
11 Amino Acids
Research Format
Lyophilized
What Is ARA-290 Peptide?
ARA-290 (cibinetide) is an 11-amino-acid synthetic peptide developed from the three-dimensional structure of erythropoietin. Research into the compound has focused on separating EPO-associated tissue-protective signaling from the classical erythropoietic activity responsible for stimulating red blood-cell production.
This distinction has made ARA-290 particularly interesting to researchers investigating how EPO-related signaling pathways may participate in cellular stress responses, inflammation, tissue protection and repair-associated biology without reproducing the conventional hematopoietic activity of EPO.
ARA-290 later became widely referenced in scientific literature as cibinetide.
ARA-290 and the Innate Repair Receptor
A central area of ARA-290 research involves a receptor complex frequently referred to as the innate repair receptor (IRR).
The IRR has been described as a heteromeric receptor involving the erythropoietin receptor and the beta common receptor (βcR / CD131). Research has investigated activation of this pathway during tissue stress, injury and inflammatory signaling.
Simplified Research Pathway
ARA-290
→
Innate Repair Receptor
→
Cellular Signaling
→
Experimental Tissue-Response Pathways
Investigators have used ARA-290 as a research tool for studying signaling associated with cellular survival, inflammatory regulation and tissue-response mechanisms.
Research Context
Mechanistic findings from experimental systems do not establish
clinical efficacy or an approved therapeutic use for ARA-290.
ARA-290 vs Erythropoietin (EPO)
ARA-290 originated from research examining the biological activities of erythropoietin. EPO is best known for its role in erythropoiesis, but research has also explored signaling associated with tissue stress and cellular protection.
Erythropoietin
Classical EPO Signaling
Full-length erythropoietin is a glycoprotein hormone with a well-characterized role in stimulating red blood-cell production through classical erythropoietin receptor signaling.
ARA-290 / Cibinetide
Tissue-Protective Research
ARA-290 was designed as a small EPO-derived peptide for investigating tissue-protective receptor pathways without the classical erythropoietic activity associated with full-length EPO.
ARA-290 Research Areas
ARA-290 has been investigated across several areas of experimental and translational research. These studies examine biological mechanisms and research endpoints rather than establishing approved medical uses.
Inflammatory Signaling
Research has examined ARA-290 in experimental systems involving inflammatory signaling and innate repair receptor-associated pathways during cellular and tissue stress.
Peripheral Nerve Research
Cibinetide has been investigated in studies involving peripheral nerve biology, small nerve fibers and sensory-function research endpoints.
Tissue-Protection Research
Preclinical investigations have explored ARA-290 in models of tissue stress and injury to better understand EPO-derived tissue-protective signaling mechanisms.
Cellular Repair Signaling
ARA-290 provides researchers with a defined peptide for examining receptor pathways associated with cellular stress responses, survival signaling and repair-associated biology.
ARA-290 and Small Fiber Neuropathy Research
One of the better-known areas of cibinetide research involves small fiber neuropathy. Clinical research has investigated ARA-290 in populations with disorders associated with small nerve-fiber dysfunction.
Researchers have evaluated endpoints involving small nerve-fiber structure, sensory function and patient-reported outcomes to examine the biological effects associated with innate repair receptor signaling.
These investigations are important scientifically because they extend ARA-290 research beyond isolated cell systems into controlled human research environments while continuing to examine its underlying biological mechanisms.
Important Distinction
Research involving neuropathy does not mean ARA-290 is approved to
diagnose, prevent or treat neuropathy. Cibinetide remains an
investigational research compound.
ARA-290 and Inflammation Research
Another major area of scientific interest involves the relationship between ARA-290 and inflammatory signaling.
Tissue injury and cellular stress can activate complex inflammatory signaling networks. Research into the innate repair receptor has examined whether EPO-derived signaling can influence these responses while simultaneously participating in tissue-protective mechanisms.
ARA-290 therefore provides a useful experimental compound for investigating the intersection between inflammatory biology, cellular stress responses and repair-associated signaling.
ARA-290 Structure and Research Characteristics
ARA-290 is considerably smaller than full-length erythropoietin. Its 11-amino-acid structure was developed to reproduce specific structural characteristics associated with the tissue-protective region of EPO.
The compact structure allows researchers to investigate a defined EPO-derived signaling sequence independently from the much larger parent glycoprotein.
11-Amino-Acid Peptide
Compact synthetic peptide derived from EPO-associated structural
research.
Non-Erythropoietic Research
Developed to investigate tissue-protective pathways separately
from classical red blood-cell stimulation.
Receptor-Focused Research
Frequently investigated in connection with innate repair
receptor signaling.
ARA-290 Peptide Research Specifications
Compound
ARA-290
Alternative Name
Cibinetide
Classification
EPO-Derived Research Peptide
Length
11 Amino Acids
Form
Lyophilized Research Material
Research Focus
Innate Repair Receptor
Why Is ARA-290 Studied?
ARA-290 occupies an interesting position in peptide research because it was designed around a specific biological question: can tissue-protective EPO signaling be investigated independently of EPO's classical hematopoietic activity?
This has led researchers to examine cibinetide across models involving innate repair receptor activation, inflammatory signaling, peripheral nerve biology, tissue stress and cellular repair mechanisms.
ARA-290 also illustrates how researchers can derive small, functionally focused peptide sequences from substantially larger biological signaling molecules.
ARA-290 Peptide FAQ
What is ARA-290 peptide?
ARA-290 is an 11-amino-acid synthetic peptide derived from structural research involving erythropoietin. It has been investigated primarily for its interaction with tissue-protective and innate repair receptor-associated signaling pathways.
Is ARA-290 the same as cibinetide?
Yes. Cibinetide is the name commonly used in scientific literature for the investigational peptide originally known as ARA-290.
Is ARA-290 the same as erythropoietin?
No. Erythropoietin is a much larger glycoprotein hormone. ARA-290 is a small synthetic peptide derived from structural research into a tissue-protective region associated with EPO.
What is the innate repair receptor?
The innate repair receptor is a receptor complex studied in connection with tissue stress and protective signaling. Research literature commonly describes it as involving the erythropoietin receptor together with the beta common receptor, also known as CD131.
What is ARA-290 researched for?
ARA-290 has been investigated in research involving innate repair receptor signaling, inflammation, tissue-protective mechanisms, peripheral nerve biology, small nerve fibers and cellular stress responses.
Has ARA-290 been studied in humans?
Yes. Cibinetide has been investigated in human clinical research, including studies examining small fiber neuropathy-related endpoints. Clinical investigation does not establish regulatory approval or therapeutic efficacy.
Does ARA-290 stimulate red blood-cell production?
ARA-290 was specifically developed for research into tissue-protective EPO-related signaling without reproducing the classical erythropoietic activity of full-length erythropoietin.
Is ARA-290 approved for human use?
No. ARA-290 / cibinetide is an investigational research compound and is not an approved medication. Royal Peptides supplies this material strictly for laboratory research purposes.
For Research Use Only
ARA-290 (cibinetide) is supplied strictly for laboratory, analytical
and research purposes. It is not intended for human or veterinary use,
consumption, diagnosis, treatment, prevention or mitigation of any
disease or medical condition. Information presented on this page
describes areas of scientific investigation and does not constitute
medical advice or evidence of clinical efficacy.
PRODUCT REFERENCE
Specifications
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ProductARA-290 Peptide (Cibinetide)
CategoryAll Products
Choose an option20mg vial, 10mg vial, 10mg Kit (100mg), 20mg Kit (200mg), 30mg Kit (300mg)
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